The intra -day accuracy ranged from -4.59% to 12.91% with a precision from 1.42% to 6.79%. The calibration curve was linear in the range of 15
The mobile phase was filtered under vacuum through 0.45 µm nylon membrane filter (Whatman International, England) and degassed before used. ID, Phenomenex, USA) fitted with a refillable guard column (Upchurch Scientific, Oak Harbour, WA, USA) packed with Perisorb RP-18 (30-40 ?m, pellicular) was used for chromatographic separation. The analytical column Luna C18 (5 ?m, 250 x 4.6 mm The mobile phase was isocratically pumped at a flow rate of 1 mL/min. The mobile phase pH was adjusted to 6 by using glacial acetic acid. The mobile phase was consisted of 0.01 M phosphoric acid, acetonitrile and methanol (84:12:4, v/v) with addition of Triethylamine Nm, respectively with the gain was set at 4 and sensitivity at medium. The HPLC system was operated at an excitation and emission wavelengths of 300 nm and 365 Reversed-phase high performance liquid chromatographic method forĭetermination of sulpiride in human plasma. The present study was aimed to develop and validate a simple Mallikarjun Chitneni, Fadli Asmani and Eddy Yusuf
WITH FLUORESCENCE DETECTION FOR SULPIRIDE DETERMINATION IN HUMAN PLASMA, *Mohammed Kaleemullah, Yusrida Darwis, Peh Kok Yang, Jiyauddin Khan, They are goodĬandidates for further pharmacological investigations.ģ HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD The extracts of the leaves of Coriaria myrtifolia showed a low toxicity. After sixty days, the extract ofĬoriaria myrtifolia did produced the increase of neutrophils and decrease of lymphocytes. The results showed no toxicity and mortality in either sexĬomparing to the control group. Wistar rats were analyzed for body weight, bloodĬhemical. No mortality or signs of toxicity were observed in theĪcute study. Oral administration with the extract at dose 200 mg/kg to Wistar ratsįor sixty days. The study of sub-chronic toxicity was evaluated by daily For acute toxicity, a single oralĪdministration was performed at a dose of 2000 mg/kg body weight in Investigated t he acute and sub-chronic toxicity of the crude methanolicĮxtract of leaves of Coriaria myrtifolia. It is an Herbal plant commonly used in western Mediterranean area. It has the largest fruits in the genus Coriaria. AarabĬoriaria myrtifolia belongs to the Coriariacae’s family. Ait el Cadi,B.Meddah, A.Zellou, A.Bounihi and L. Needed to be developed, that is a new challenge and felt more furtherĬonsidering the side effects that drugs have.Ģ ACUTE AND SUB-CHRONIC TOXICITY STUDY OF CORIARIA MYRTIFOLIA LEAVES EXTRACT IN RODENTS, M. Have the activity as the central nervous system (CNS) depressant The new compound which have a spesific action is theĬompound is doing by the synthesis from some reactans and the very
Pharmacological effect to become the new molecul drug is a challenge The development of drug molecules which have a spesific activity of 1 N-(3-TRIFLUOROMETHYLBENZOYL)-N’PHENYLUREA,A NOVEL COMPOUND OF THE CENTRAL NERVOUS SYSTEM
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